Alastair Cook will captain England on their tour of Bangladesh after the selectors opted to rest both Andrew Strauss and James Anderson.
Cook, whose previous leadership experience is limited to a brief spell with England Under 19s, will take charge of a 16-man Test squad to face the Tigers.
The Essex opener will also lead England's 15-man party for the three one-day internationals, although Paul Collingwood retains the T20 captaincy for the two fixtures against Pakistan in the United Arab Emirates which precede the team's arrival in Bangladesh.
Pace spearhead Anderson has been left out in order to undergo a specialist review and a programme of rehabilitation for his chronic right knee injury. It is anticipated that following the rehabilitation period, he will be fully fit and available for selection for the World T20 in the West Indies in late April.
Two uncapped players, Yorkshire fast bowler Ajmal Shahzad and Kent off-spinner James Tredwell, have won places in both squads, while Hampshire batsman Michael Carberryhas been included for the Tests.
There is, however, no place for a third spinner in either squad as both Monty Panesar and Adil Rashid have been overlooked.
"Andrew Strauss has provided outstanding leadership for the team in both forms of the game over the past 12 months and the selectors feel it is important that he takes a break ahead of an extremely busy programme of international cricket leading up to and including the Ashes series in Australia and the ICC Cricket World Cup in 2011," explained national selector Geoff Miller.
"Our decision to appoint Alastair Cook to the Test vice captaincy last year clearly demonstrated the belief that he has the potential to be a future England captain.
"Alastair will now have an opportunity to develop his leadership skills still further by leading the side in both forms of cricket in Bangladesh and I know that he is excited by the challenge and looking forward to working closely with Andy Flower.
"Paul Collingwood had an excellent tour of South Africa in all forms of cricket and he will continue to lead the side in the T20 format with the two T20 Internationals against the current World champions Pakistan providing excellent preparation for us ahead of the World T20 in the Caribbean."
On the new faces, Miller added: "We are delighted to welcome Ajmal Shahzad to both squads for the first time.
"He enjoyed an excellent season with Yorkshire last year, made a strong impression while he was in South Africa with the EPP squad and is a bowler with the potential to make a real impact in international cricket. "
"James Tredwell and Michael Carberry have also continued to impress the selectors over the course of the winter and we expect both players to make a strong challenge for inclusion in our starting line-up on the forthcoming tour."
England head to UAE for two T20 internationals against Pakistan on February 19 and 20.
The three-match one-day international series against Bangladesh runs from February 28-March 5 followed by Tests in Chittagong (Mar 12-16) and Dhaka (Mar 20-24).